Oral treatment of mansoni schistosomiasis: results obtained from the use of miracil D hydrochloride (20 day-regimen) and of stannous oxide

Abstract

The authors employed the scheme of treatment for schistosomiasis suggested by HALAWANI et al. (1955). Nine adults with mansonic schistosomiasis were given Miracil D hydrochloride in two or three daily doses for 20 days. Each dose consisted of a 200 mgm. Tablet. The following toxic side-effects were frequent among patients: nausea, vomiting, inappetence, diarrhea, abdominal pain, weakness, malaise, giddiness and insomnia. No parasitologic cure was obtained. Bilharstan, a stannous oxyde pharmaceutical was employed in the treatment of two other patients with mansonic schistosomiasis. Fecal elimination of eggs continued after treatment in both cases, which confirms previous findings by the authors and contradicts the report of MAUZÉ and ARNAUD (1954). These patients were given eight 0.5 gm. tablets daily for eight days in three series separated by an interval of one week between any two series.